tumor promotion

By Targets:	COX (1) Microtubule/Tubulin (1) PKC (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (1)

Targets Recommended: TNF Receptor BRK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14617

Paradol 3 Publications Verification [6]-Gingerone; [6]-Paradol	COX	Cancer
Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.

HY-N10390

3β-Hydroxylanosta-8,24-dien-21-al	Others	Cancer
3β-Hydroxylanosta-8,24-dien-21-al is a lanostane-type triterpene. 3β-Hydroxylanosta-8,24-dien-21-al can inhibit the tumor promotion, reducing the percentage of mice bearing papillomas .

HY-161248

E7130	Microtubule/Tubulin	Cancer
E7130 is a microtubule inhibitor, which ameliorates the tumor microenvironment through suppression of cancer-associated fibroblasts (CAF) and promotion of tumor vasculature remodeling .

HY-N8449

Ailanthoidol	Others	Inflammation/Immunology Cancer
Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion .

HY-P3842

Protein Kinase C (661-671)	PKC	Cancer
Protein Kinase C (661-671) is a fragment peptide of β1 subspecies of protein kinase C (PKC). PKC plays a role in cellular growth control and tumor promotion .

HY-N1687

21,24-Epoxycycloartane-3,25-diol	Others	Others
21,24-Epoxycycloartane-3,25-diol (compound 15 or 16) is a cycloartanoid triterpene that can be isolated from the leaves of Lansium domesticum. 21,24-Epoxycycloartane-3,25-diol inhibits skin-tumor promotion .

Cat. No.	Product Name

HY-L100

Tumorigenesis-Related Compound Library	129 compounds
Cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. The administration of chemical carcinogens is one of the most commonly used methods to induce tumors in several organs in laboratory animals in order to study oncologic diseases of humans. MCE offers a unique collection of 129 chemical carcinogens which have been identified with carcinogenic activity either in humans or in animal models. MCE Tumorigenesis-Related Compound Library is a powerful tool for studying oncologic diseases of humans. Standard opration based on safety data sheet will not cause harm to the body.

Tumorigenesis-Related Compound Library

129 compounds

Cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. The administration of chemical carcinogens is one of the most commonly used methods to induce tumors in several organs in laboratory animals in order to study oncologic diseases of humans. MCE offers a unique collection of 129 chemical carcinogens which have been identified with carcinogenic activity either in humans or in animal models. MCE Tumorigenesis-Related Compound Library is a powerful tool for studying oncologic diseases of humans. Standard opration based on safety data sheet will not cause harm to the body.

Cat. No.	Product Name	Target	Research Area

HY-P3842

Protein Kinase C (661-671)	PKC	Cancer
Protein Kinase C (661-671) is a fragment peptide of β1 subspecies of protein kinase C (PKC). PKC plays a role in cellular growth control and tumor promotion .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14617

Paradol 3 Publications Verification [6]-Gingerone; [6]-Paradol	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer Zingiberaceae	COX
Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.

HY-N10390

3β-Hydroxylanosta-8,24-dien-21-al	Natural Products Microorganisms Source classification	Others
3β-Hydroxylanosta-8,24-dien-21-al is a lanostane-type triterpene. 3β-Hydroxylanosta-8,24-dien-21-al can inhibit the tumor promotion, reducing the percentage of mice bearing papillomas .

HY-N8449

Ailanthoidol	Structural Classification Monophenols Classification of Application Fields Zanthoxylum chalybeum Engl. Source classification Lignans Rutaceae Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Others
Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion .

HY-N1687

21,24-Epoxycycloartane-3,25-diol	Triterpenes Structural Classification Terpenoids Lansium domesticum Corrêa Source classification Plants Meliaceae	Others
21,24-Epoxycycloartane-3,25-diol (compound 15 or 16) is a cycloartanoid triterpene that can be isolated from the leaves of Lansium domesticum. 21,24-Epoxycycloartane-3,25-diol inhibits skin-tumor promotion .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products